| Dan Castellaneta | Homer Simpson/Grampa/Barney Gumble/Krusty the Klown/Groundskeeper Willie/Mayor Quimby/Hans Moleman/Sideshow Mel/Others |
| Julie Kavner | Marge Simpson/Patty & Selma Bouvier/Others |
| Nancy Cartwright | Bart Simpson/Nelson Muntz/Todd Flanders/Ralph Wiggum/Kearney/Others |
| Yeardley Smith | Lisa Simpson |
| Hank Azaria | Moe Szyslak/Chief Wiggum/Apu/Comic Book Guy/Cletus/Prof. Frink/Others |
| Harry Shearer | Montgomery Burns/Waylon Smithers/Ned Flanders/Kent Brockman/Rev. Lovejoy/Principal Skinner/Dr. Hibbert/Rainer Wolfcastle/Others |
| Marcia Wallace | Edna Krabappel (1990-) |
| Phil Hartman | Lionel Hutz/Troy McClure (1991-1998) |
| Tress MacNeille | Jimbo Jones/Agnes Skinner/Others |
| Pamela Hayden | Milhouse Van Houten/Rod Flanders/Others |
| Maggie Roswell | Maude Flanders/Helen Lovejoy/Others (1990-1999, 2002-) |
| Russi Taylor | Martin Prince/Others (1990-) |
| Doris Grau | Lunchlady Doris (1989-1996) |
| Karl Wiedergott | Additional Voices (1998-) |
| Marcia Mitzman Gaven | Maude Flanders/Helen Lovejoy/Others (1999-2002) |
| Jo Ann Harris | Additional Voices (1989-1992) |
